Narcolepsy and familial advanced sleep-phase syndrome: molecular genetics of sleep disorders.

Details

Serval ID
serval:BIB_221C534D0F15
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Narcolepsy and familial advanced sleep-phase syndrome: molecular genetics of sleep disorders.
Journal
Current Opinion in Genetics and Development
Author(s)
Tafti M., Dauvilliers Y., Overeem S.
ISSN
0959-437X[print], 0959-437X[linking]
Publication state
Published
Issued date
2007
Peer-reviewed
Oui
Volume
17
Number
3
Pages
222-227
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review Publication Status: ppublish
Abstract
Sleep disorders are very prevalent and represent an emerging worldwide epidemic. However, research into the molecular genetics of sleep disorders remains surprisingly one of the least active fields. Nevertheless, rapid progress is being made in several prototypical disorders, leading recently to the identification of the molecular pathways underlying narcolepsy and familial advanced sleep-phase syndrome. Since the first reports of spontaneous and induced loss-of-function mutations leading to hypocretin deficiency in human and animal models of narcolepsy, the role of this novel neurotransmission pathway in sleep and several other behaviors has gained extensive interest. Also, very recent studies using an animal model of familial advanced sleep-phase syndrome shed new light on the regulation of circadian rhythms.
Keywords
Animals, Genetic Predisposition to Disease/genetics, Humans, Narcolepsy/genetics, Narcolepsy/pathology, Sleep Disorders, Circadian Rhythm/genetics, Sleep Disorders, Circadian Rhythm/pathology
Pubmed
Web of science
Create date
24/01/2008 15:55
Last modification date
20/08/2019 12:59
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