Radiochimiothérapie dans les cancers ORL (EGFR+) [Radio-chemotherapy in head and neck cancer (EGFR+)].

Details

Serval ID
serval:BIB_204AB02D8A2B
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Radiochimiothérapie dans les cancers ORL (EGFR+) [Radio-chemotherapy in head and neck cancer (EGFR+)].
Journal
Bulletin du Cancer
Author(s)
Ozsahin M., Matzinger O., Zimmermann M., Zouhair A.
ISSN
1769-6917 (Electronic)
ISSN-L
0007-4551
Publication state
Published
Issued date
2007
Volume
94
Number
9
Pages
828-832
Language
french
Notes
Publication types: English Abstract ; Journal Article ; Review Publication Status: ppublish
Abstract
Squamous-cell carcinoma of the head and neck are neoplasic diseases for which locoregional control remains very important, given its particular pattern of failure. Treatment of early stage disease involves surgery or radiation therapy. Locally advanced disease is treated either with concurrent chemoradiotherapy or surgery followed by radio-chemotherapy, according to each center's expertise. Recent research has demonstrated that the overexpression of epidermal growth factor receptor (EGFR) is associated with tumor progression. Based on this research, a new type of anticancer therapy, so-called "targeted therapies" represent important additions to the current therapeutic arsenal in the management of head and neck cancers, based on results of a phase III trial combining radiotherapy and immunotherapy with cetuximab.
Keywords
Antineoplastic Agents/therapeutic use, Carcinoma, Squamous Cell/chemistry, Carcinoma, Squamous Cell/drug therapy, Chemotherapy, Adjuvant, Clinical Trials, Phase III as Topic/statistics & numerical data, Drug Delivery Systems, Head and Neck Neoplasms/chemistry, Head and Neck Neoplasms/drug therapy, Humans, Neoplasm Proteins/antagonists & inhibitors, Neoplasm Recurrence, Local/prevention & control, Radiotherapy, Adjuvant, Randomized Controlled Trials as Topic/statistics & numerical data, Receptor, Epidermal Growth Factor/antagonists & inhibitors, Treatment Outcome
Pubmed
Web of science
Create date
24/01/2008 17:20
Last modification date
20/08/2019 12:56
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