Generalization of ionic partition diagrams to lipophilic compounds and to biphasic systems with variable phase volume ratios.

Details

Serval ID
serval:BIB_20392
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Generalization of ionic partition diagrams to lipophilic compounds and to biphasic systems with variable phase volume ratios.
Journal
Journal of the American Chemical Society
Author(s)
Gobry V., Ulmeanu S., Reymond F., Bouchard G., Carrupt P.A., Testa B., Girault H.H.
ISSN
0002-7863 (Print)
ISSN-L
0002-7863
Publication state
Published
Issued date
2001
Volume
123
Number
43
Pages
10684-10690
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
The ionic partition diagram methodology has been generalized to address both hydrophilic and lipophilic compounds and to consider biphasic systems with variable phase volume ratios. With this generalized approach electrochemical measurements of ion transfer potentials afford the determination of the standard partition coefficients of all forms of ionizable molecules, including the neutral form, as well as the evaluation of the dissociation constant of monoprotic substances. An interesting consequence of this approach is the definition of an extraction pK(a,ext) which is the apparent pK(a) of neutral acids and bases when dissolved in the organic phase.
Keywords
2,4-Dinitrophenol/chemistry, Acids/chemistry, Aniline Compounds/chemistry, Electrochemistry, Hydrogen-Ion Concentration, Ions/chemistry, Kinetics, Lipids/chemistry, Solubility, Thermodynamics, Water/chemistry
Pubmed
Create date
19/11/2007 9:43
Last modification date
20/08/2019 12:56
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