La régression tumorale n'est pas un facteur de risque d'atteinte du ganglion sentinelle dans les mélanomes fins (indice de Breslow < or = 1 mm) [Tumour regression is not predictive for higher risk of sentinel node involvement in thin melanomas (Breslow thickness < or = 1 mm)]

Details

Serval ID
serval:BIB_1F97A4FDFF6E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
La régression tumorale n'est pas un facteur de risque d'atteinte du ganglion sentinelle dans les mélanomes fins (indice de Breslow < or = 1 mm) [Tumour regression is not predictive for higher risk of sentinel node involvement in thin melanomas (Breslow thickness < or = 1 mm)]
Journal
Annales de Dermatologie et de Vénéréologie
Author(s)
Kramkimel N., Maubec E., Boitier F., Cavalcanti A., Beldi M., Mamelle G., Kolb F., Duvillard P., Avril M.F.
ISSN
0151-9638[print], 0151-9638[linking]
Publication state
Published
Issued date
2010
Volume
137
Number
4
Pages
276-280
Language
french
Abstract
Background:
Thin melanomas (Breslow thickness <= 1 mm) are considered highly curable. The aim of this study was to evaluate the correlation between histological tumour regression and sentinel lymph node (SLN) involvement in thin melanomas.
Patients and methods:
This was a retrospective single-centre study of 34 patients with thin melanomas undergoing SLN biopsy between April 1998 and January 2005.
Results:
The study included 14 women and 20 men of mean age 56.3 years. Melanomas were located on the neck (n = 3), soles (n = 4), trunk (n = 13) and extremities (n = 14). Pathological examination showed 25 SSM, four acral lentiginous melanomas, three in situ melanomas, one nodular melanoma and one unclassified melanoma with a mean Breslow thickness of 0.57 mm. Histological tumour regression was observed in 26 over 34 cases and ulceration was found in one case. Clark levels were as follows: I (n = 3), II (n = 20), III (n = 9), IV (n = 2). Growth phase was available in 15 cases (seven radial and eight vertical). Mitotic rates, available in 24 cases, were: 0 (n = 9), 1 (n = 11), 2 (n = 2), 3 (n = 1), 6 (n = 1). One patient with histological tumour regression (2.9% of cases and 3.8% of cases with regressing tumours) had a metastatic SLN. One patient negative for SLN had a lung relapse and died of the disease. Mean follow-up was 26.2 months.
Conclusion:
The results of the present study and the analysis of the literature show that histological regression of the primary tumour does not seem predictive of higher risk of SLN involvement in thin melanomas. This suggests that screening for SLN is not indicated in thin melanomas, even those with histological regression.
Keywords
Thin Melanoma, Histological Tumour Regression, Sentinel Lymph Node Biopsy, Primary Cutaneous Melanoma, American Joint Committee, Less-Than-or-Equal-To-1 MM, Malignant-Melanoma, Biopsy, Lymphadenectomy, Metastasis
Pubmed
Web of science
Create date
14/06/2010 12:37
Last modification date
20/08/2019 12:55
Usage data