The international sepsis forum consensus conference on definitions of infection in the intensive care unit

Détails

ID Serval
serval:BIB_1E134EA47365
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
The international sepsis forum consensus conference on definitions of infection in the intensive care unit
Périodique
Critical Care Medicine
Auteur(s)
Calandra  T., Cohen  J.
ISSN
0090-3493 (Print)
Statut éditorial
Publié
Date de publication
07/2005
Volume
33
Numéro
7
Pages
1538-48
Notes
Consensus Development Conference
Journal Article
Research Support, Non-U.S. Gov't
Review --- Old month value: Jul
Résumé
OBJECTIVE: To develop definitions of infection that can be used in clinical trials in patients with sepsis. CONTEXT: Infection is a key component of the definition of sepsis, yet there is currently no agreement on the definitions that should be used to identify specific infections in patients with sepsis. Agreeing on a set of valid definitions that can be easily implemented as part of a clinical trial protocol would facilitate patient selection, help classify patients into prospectively defined infection categories, and therefore greatly reduce variability between treatment groups. DESIGN AND METHODS: Experts in infectious diseases, clinical microbiology, and critical care medicine were recruited and allocated specific infection sites. They carried out a systematic literature review and used this, and their own experience, to prepare a draft definition. At a subsequent consensus conference, rapporteurs presented the draft definitions, and these were then refined and improved during discussion. Modifications were circulated electronically and subsequently agreed upon as part of an iterative process until consensus was reached. RESULT: Consensus definitions of infection were developed for the six most frequent causes of infections in septic patients: pneumonia, bloodstream infections (including infective endocarditis), intravascular catheter-related sepsis, intra-abdominal infections, urosepsis, and surgical wound infections. CONCLUSIONS: We have described standardized definitions of the common sites of infection associated with sepsis in critically ill patients. Use of these definitions in clinical trials should help improve the quality of clinical research in this field.
Mots-clé
Clinical Trials Cross Infection/classification/diagnosis Humans *Intensive Care Units Patient Selection Sepsis/*classification/*diagnosis/etiology Shock, Septic/classification/diagnosis Systemic Inflammatory Response Syndrome/classification/diagnosis *Terminology
Pubmed
Web of science
Création de la notice
25/01/2008 14:28
Dernière modification de la notice
03/03/2018 14:35
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