Pregnancy impairs resistance of C57BL/6 mice to Leishmania major infection.

Détails

ID Serval
serval:BIB_1D8A69D09F63
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Pregnancy impairs resistance of C57BL/6 mice to Leishmania major infection.
Périodique
African Journal of Medicine and Medical Sciences
Auteur(s)
Arinola O.G., Louis J.S., Tacchini-Cottier F., Aseffa A., Salimonu L.S.
ISSN
0309-3913 (Print)
ISSN-L
0309-3913
Statut éditorial
Publié
Date de publication
2005
Volume
34
Numéro
1
Pages
65-70
Langue
anglais
Résumé
To determine if gestational factors affect the severity of L. major infection, this study assessed the levels of IL-4 mRNA and IFN-gamma mRNA in popliteal lymph node cells of pregnant C57BL/6 mice mated at 5 hours, 16 hours and 15 days post L. major infection using PCR. Infected pregnant C57BL/6 mice developed larger cutaneous footpad lesions compared with non-pregnant infected C57BL/6 mice. The resolution of footpad lesions commenced after 8th week in C57BL/6 mice mated at 16 hrs post L. major infection but 12 weeks in C57BL/6 mice mated at 5 hrs and 15 days post L. major infection. C57BL/6 mice that were infected 20 days post partum resolved L. major infection effectively. But, the lesions in infected pregnant C57BL/6 mice and infected non-pregnant C57BL/6 mice were not as large as in susceptible BALB/c mice. The mean litter weights were similar in pregnant infected C57BL/6 mice mated at different stages of L. major infection but were slightly lower than weights of litters from pregnant uninfected C57BL/6 mice. In 5 days infected pregnant C57BL/6 mice, the levels of IFN-gamma were raised compared with the levels of IL-4 but those mated at 15 days post L. major infection had highest level of IFN-gamma mRNA. In 10 days pregnant infected C57BL/6 mice, levels of IL-4 were raised compared with IFN-gamma but mice mated at 16 hrs post L. major infection had highest level of IL-4. In 15 days pregnant infected mice, the levels of IL-4 were higher than IFN-gamma irrespective of the stage of L. major infection when the mice were mated. Mice infected with L. major 20 days post-partum produced more IFN-gamma than IL-4 from 16 hrs post L. major infection onwards. It may be concluded that increased IL-4 in pregnant infected C57BL/6 mice impairs the resistance of C57BL/6 mice to L. major infection especially in mice that were pregnant before effective immunity (5 hours post L. major infection) is mounted against L. major infection.
Mots-clé
Animals, Female, Host-Parasite Interactions, Interleukin-4, Leishmania major/pathogenicity, Leishmaniasis, Cutaneous/immunology, Mice, Mice, Inbred C57BL, Pregnancy, Pregnancy Complications, Parasitic/immunology, Risk Factors, Th1 Cells, Th2 Cells
Pubmed
Création de la notice
24/01/2008 16:09
Dernière modification de la notice
20/08/2019 13:53
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