Development of functional human embryonic stem cell-derived neurons in mouse brain.

Details

Serval ID
serval:BIB_1CC6A20D1A6D
Type
Article: article from journal or magazin.
Collection
Publications
Title
Development of functional human embryonic stem cell-derived neurons in mouse brain.
Journal
Proceedings of the National Academy of Sciences of the United States of America
Author(s)
Muotri A.R., Nakashima K., Toni N., Sandler V.M., Gage F.H.
ISSN
0027-8424
Publication state
Published
Issued date
2005
Peer-reviewed
Oui
Volume
102
Number
51
Pages
18644-18648
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Human embryonic stem cells are pluripotent entities, theoretically capable of generating a whole-body spectrum of distinct cell types. However, differentiation of these cells has been observed only in culture or during teratoma formation. Our results show that human embryonic stem cells implanted in the brain ventricles of embryonic mice can differentiate into functional neural lineages and generate mature, active human neurons that successfully integrate into the adult mouse forebrain. Moreover, this study reveals the conservation and recognition of common signals for neural differentiation throughout mammalian evolution. The chimeric model will permit the study of human neural development in a live environment, paving the way for the generation of new models of human neurodegenerative and psychiatric diseases. The model also has the potential to speed up the screening process for therapeutic drugs.
Keywords
Animals, Animals, Newborn, Brain/cytology, Brain/growth & development, Cell Differentiation, Cell Line, Chimerism, Embryo, Mammalian/cytology, Humans, Mice, Neurons/cytology, Stem Cell Transplantation, Stem Cells/cytology
Pubmed
Web of science
Open Access
Yes
Create date
22/01/2010 7:50
Last modification date
20/08/2019 12:53
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