Modelling body mass index and endometrial cancer risk in a pooled-analysis of three case-control studies.

Détails

ID Serval
serval:BIB_1C3659CD5D19
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Modelling body mass index and endometrial cancer risk in a pooled-analysis of three case-control studies.
Périodique
Bjog : An International Journal of Obstetrics and Gynaecology
Auteur(s)
Rota M., Rumi F., Bagnardi V., Dal Maso L., Zucchetto A., Levi F., La Vecchia C., Tavani A.
ISSN
1471-0528 (Electronic)
ISSN-L
1470-0328
Statut éditorial
Publié
Date de publication
2016
Volume
123
Numéro
2
Pages
285-292
Langue
anglais
Notes
Publication types: Journal Article ; Meta-Analysis ; Multicenter Study ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
OBJECTIVE: To quantify the relation between body mass index (BMI) and endometrial cancer risk, and to describe the shape of such a relation.
DESIGN: Pooled analysis of three hospital-based case-control studies.
SETTING: Italy and Switzerland.
POPULATION: A total of 1449 women with endometrial cancer and 3811 controls.
METHODS: Multivariate odds ratios (OR) and 95% confidence intervals (95% CI) were obtained from logistic regression models. The shape of the relation was determined using a class of flexible regression models.
MAIN OUTCOME MEASURE: The relation of BMI with endometrial cancer.
RESULTS: Compared with women with BMI 18.5 to <25 kg/m(2) , the odds ratio was 5.73 (95% CI 4.28-7.68) for women with a BMI ≥35 kg/m(2) . The odds ratios were 1.10 (95% CI 1.09-1.12) and 1.63 (95% CI 1.52-1.75) respectively for an increment of BMI of 1 and 5 units. The relation was stronger in never-users of oral contraceptives (OR 3.35, 95% CI 2.78-4.03, for BMI ≥30 versus <25 kg/m(2) ) than in users (OR 1.22, 95% CI 0.56-2.67), and in women with diabetes (OR 8.10, 95% CI 4.10-16.01, for BMI ≥30 versus <25 kg/m(2) ) than in those without diabetes (OR 2.95, 95% CI 2.44-3.56). The relation was best fitted by a cubic model, although after the exclusion of the 5% upper and lower tails, it was best fitted by a linear model.
CONCLUSIONS: The results of this study confirm a role of elevated BMI in the aetiology of endometrial cancer and suggest that the risk in obese women increases in a cubic nonlinear fashion. The relation was stronger in never-users of oral contraceptives and in women with diabetes.
Mots-clé
Body Mass Index, Case-Control Studies, Endometrial Neoplasms/epidemiology, Endometrial Neoplasms/etiology, Female, Humans, Italy/epidemiology, Logistic Models, Obesity/complications, Obesity/epidemiology, Odds Ratio, Risk Factors, Switzerland/epidemiology
Pubmed
Web of science
Création de la notice
17/11/2015 16:10
Dernière modification de la notice
03/03/2018 14:32
Données d'usage