Hypercalcitoninemia and thyroid nodules: when cytology (still) matters.

Details

Serval ID
serval:BIB_1B91CC4CCBC0
Type
Article: article from journal or magazin.
Collection
Publications
Title
Hypercalcitoninemia and thyroid nodules: when cytology (still) matters.
Journal
Diagnostic Cytopathology
Author(s)
Giovanella L., Giugliano G., Maffini F.A., Chiesa F., Bongiovanni M.
ISSN
1097-0339 (Electronic)
ISSN-L
1097-0339
Publication state
Published
Issued date
2014
Volume
42
Number
11
Pages
970-973
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
Medullary thyroid carcinoma (MTC) can assume various cytomorphological and architectural forms, mimicking other thyroid and extra-thyroid tumors and rendering the cytological and histological diagnosis challenging. Consequently, measurement of calcitonin (CT) levels is generally considered to be more accurate than cytology in diagnosing MTC. Here, we report on a patient with a multinodular goiter and significantly elevated basal CT levels; based on cytology examination and CT immunocytostains, neither MTC nor C-cell hyperplasia was detected upon final histopathological examination. CT testing has a high false-positive rate and low positive predictive value for detecting clinically relevant MTC. Judicious integration of cytological examination with immunocytochemical stains (when needed) may be useful for selecting the most appropriate therapy and avoiding overtreatment (i.e., central neck lymph node dissection in the present case). This case demonstrates that cytological examination with ancillary techniques is still valuable in patients with thyroid nodules and suspicious MTC.
Pubmed
Web of science
Create date
21/01/2015 9:40
Last modification date
20/08/2019 12:52
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