Article: article from journal or magazin.
Restricted expression of the erythroid/brain glucose transporter isoform to perivenous hepatocytes in rats. Modulation by glucose.
Journal of Clinical Investigation
The "erythroid/brain" glucose transporter (GT) isoform is expressed only in a subset of hepatocytes, those forming the first row around the terminal hepatic venules, while the "liver" GT is expressed in all hepatocytes. After 3 d of starvation, a three- to fourfold elevation of expression of the erythroid/brain GT mRNA and protein is detected in the liver as a whole; this correlates with the expression of this GT in more hepatocytes, those forming the first three to four rows around the hepatic venules. Starvation-dependent expression of the erythroid/brain GT on the plasma membrane of these additional hepatocytes is lost within 3 h of glucose refeeding; however, by immunoblotting we show that the protein is still present. Its loss from the surface is possibly explained by internalization.
Animals, Blotting, Northern, Blotting, Western, Cell Membrane, Fluorescent Antibody Technique, Gene Expression, Glucose, Liver, Monosaccharide Transport Proteins, RNA, Messenger, Rats, Rats, Inbred Strains, Starvation, Time Factors, Tissue Distribution
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