Level and change in cognitive test scores predict risk of first stroke.
Details
Serval ID
serval:BIB_1B31185241E4
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Level and change in cognitive test scores predict risk of first stroke.
Journal
Journal of the American Geriatrics Society
ISSN
1532-5415 (Electronic)
ISSN-L
0002-8614
Publication state
Published
Issued date
03/2009
Peer-reviewed
Oui
Volume
57
Number
3
Pages
499-505
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Abstract
To determine whether cognitive test scores and cognitive decline predict incidence of first diagnosed stroke.
Stroke-free Health and Retirement Study participants were followed on average 7.6 years for self- or proxy-reported first stroke (1,483 events). Predictors included baseline performance on a modified Telephone Interview for Cognitive Status (Mental Status) and Word Recall test and decline between baseline and second assessment in either measure. Hazard ratios (HRs) were estimated using Cox proportional hazards models for the whole sample and stratified according to five major cardiovascular risk factors.
National cohort study of noninstitutionalized adults with a mean baseline age of 64+/-9.9.
Health and Retirement Study participants (n=19,699) aged 50 and older.
Word Recall (HR for 1 standard deviation difference=0.92, 95% confidence interval (CI)=0.86-0.97)) and Mental Status (HR=0.89, 95% CI=0.84-0.95) predicted incident stroke. Mental Status predicted stroke risk in those with (HR=0.93, 95%=0.87-0.99) and without (HR=0.81, 95% CI=0.72-.91) one or more vascular risk factors. Word Recall declines predicted a 16% elevation in subsequent stroke risk (95% CI=1.01-1.34). Declines in Mental Status predicted a 37% elevation in stroke risk (95% CI=1.11-1.70).
Cognitive test scores predict future stroke risk, independent of other major vascular risk factors.
Stroke-free Health and Retirement Study participants were followed on average 7.6 years for self- or proxy-reported first stroke (1,483 events). Predictors included baseline performance on a modified Telephone Interview for Cognitive Status (Mental Status) and Word Recall test and decline between baseline and second assessment in either measure. Hazard ratios (HRs) were estimated using Cox proportional hazards models for the whole sample and stratified according to five major cardiovascular risk factors.
National cohort study of noninstitutionalized adults with a mean baseline age of 64+/-9.9.
Health and Retirement Study participants (n=19,699) aged 50 and older.
Word Recall (HR for 1 standard deviation difference=0.92, 95% confidence interval (CI)=0.86-0.97)) and Mental Status (HR=0.89, 95% CI=0.84-0.95) predicted incident stroke. Mental Status predicted stroke risk in those with (HR=0.93, 95%=0.87-0.99) and without (HR=0.81, 95% CI=0.72-.91) one or more vascular risk factors. Word Recall declines predicted a 16% elevation in subsequent stroke risk (95% CI=1.01-1.34). Declines in Mental Status predicted a 37% elevation in stroke risk (95% CI=1.11-1.70).
Cognitive test scores predict future stroke risk, independent of other major vascular risk factors.
Keywords
Aged, Aged, 80 and over, Cognition Disorders/diagnosis, Cognition Disorders/epidemiology, Cohort Studies, Dementia, Vascular/diagnosis, Dementia, Vascular/epidemiology, Female, Follow-Up Studies, Humans, Interviews as Topic, Kaplan-Meier Estimate, Male, Mental Status Schedule/statistics & numerical data, Middle Aged, Predictive Value of Tests, Psychometrics/statistics & numerical data, Risk, Stroke/diagnosis, Stroke/epidemiology, United States
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Create date
18/10/2021 13:59
Last modification date
04/11/2021 6:40
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