Disseminierte Toxoplasmose bei AIDS. [Disseminated toxoplasmosis in AIDS]

Details

Serval ID
serval:BIB_1B1BF003D357
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Disseminierte Toxoplasmose bei AIDS. [Disseminated toxoplasmosis in AIDS]
Journal
Deutsche Medizinische Wochenschrift
Author(s)
Holch  A., Opravil  M., Moradpour  D., Siegenthaler  W., Schneider  J., Luthy  R.
ISSN
0012-0472 (Print)
Publication state
Published
Issued date
06/1993
Volume
118
Number
22
Pages
814-9
Notes
Case Reports
English Abstract
Journal Article --- Old month value: Jun 4
Abstract
Within one year a 46-year-old HIV-positive man developed Pneumocystis carinii pneumonia, candida oesophagitis and recurrent mucocutaneous herpes simplex infections. He finally developed a constant fever without any infection-localizing features. There was pancytopenia, increased activities of the transaminases, lactate dehydrogenase, amylase and lipase, as well as diffuse ST-segment changes in the ECG and discrete pulmonary infiltrates. The anti-toxoplasmosis titre was 8 IU/ml. Despite extensive diagnostic tests no firm diagnosis could be established. The pulmonary infiltrate and the fever regressed under antibiotic treatment with co-trimoxazole. Two months later his general condition deteriorated again with some disorientation and subfebrile temperature, epididymitis and renewed rise in abnormal laboratory values. For the first time computed tomography showed some punctate contrast-medium concentrations in the subcortical area and the medulla. The patient died on the same day. Histological material obtained at the time of autopsy revealed pseudocysts with Toxoplasma gondii and necrotizing inflammation in the brain, myocardium and lungs, as well as the entire gastrointestinal and urogenital tracts. In addition, cytomegalovirus infection of the lung and adrenals was demonstrated. Anti-toxoplasmosis IgG titre, determined postmortem, again registered a marked rise to 251 IU/ml. This suggests that there was reactivation of the toxoplasmosis as part of the immunosuppression process.
Keywords
AIDS-Related Opportunistic Infections/*diagnosis/parasitology Brain/parasitology Cytomegalovirus Infections/complications Heart/parasitology Humans Kidney/parasitology Male Middle Aged Toxoplasmosis/*complications/parasitology Toxoplasmosis, Cerebral/parasitology
Pubmed
Web of science
Create date
25/01/2008 16:05
Last modification date
20/08/2019 12:51
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