Comparison of 8-MOP aqueous bath and 8-MOP ethanolic lotion (Meladinine) in local PUVA therapy
Details
Serval ID
serval:BIB_1ADC9E44A3EA
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Comparison of 8-MOP aqueous bath and 8-MOP ethanolic lotion (Meladinine) in local PUVA therapy
Journal
Dermatology
ISSN
1018-8665 (Print)
Publication state
Published
Issued date
1998
Volume
197
Number
1
Pages
25-30
Notes
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Journal Article
Research Support, Non-U.S. Gov't
Abstract
BACKGROUND AND OBJECTIVE: Local PUVA (psoralen plus UVA light) is an effective outpatient treatment for patients with palmoplantar eczema or psoriasis. In this study, the efficacy, applicability and patient acceptance of two local forms of 8-methoxypsoralen (8-MOP) PUVA therapy were compared. METHODS: The study design was a left-right comparison (n = 37): the left hand or foot was treated with (aqueous) 8-MOP bath PUVA whereas the right received (ethanolic) 8-MOP lotion PUVA. After 1 month, the more successful treatment was continued on both sides until lesions cleared. RESULTS: Both therapies were effective and both useful for particular clinical applications: patients with erosive lesions and rhagades appreciated the gentleness of bath PUVA. Those with pustules or hyperkeratotic lesions appreciated the greater effectiveness of 8-MOP lotion PUVA. The total UVA dose and number of sessions to clearance were smaller with 8-MOP lotion. There was no difference in the length of the relapse-free period. Therapy nonresponders usually became apparent within the first 12 sessions. CONCLUSIONS: The difference between bath PUVA and lotion PUVA can be described as 'gentle' versus 'strong' therapy. The better therapy depends on clinical indication.
Keywords
Administration, Cutaneous
Adult
Baths
Dose-Response Relationship, Drug
Female
Foot Dermatoses/*drug therapy
Hand Dermatoses/*drug therapy
Humans
Male
Methoxsalen/*administration & dosage
Middle Aged
*PUVA Therapy
Photosensitizing Agents/*administration & dosage
Psoriasis/*drug therapy
Treatment Outcome
Pubmed
Web of science
Create date
25/01/2008 17:55
Last modification date
20/08/2019 13:51