Comparison of 8-MOP aqueous bath and 8-MOP ethanolic lotion (Meladinine) in local PUVA therapy

Détails

ID Serval
serval:BIB_1ADC9E44A3EA
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Comparison of 8-MOP aqueous bath and 8-MOP ethanolic lotion (Meladinine) in local PUVA therapy
Périodique
Dermatology
Auteur(s)
Shephard  S. E., Schregenberger  N., Dummer  R., Panizzon  R. G.
ISSN
1018-8665 (Print)
Statut éditorial
Publié
Date de publication
1998
Volume
197
Numéro
1
Pages
25-30
Notes
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Résumé
BACKGROUND AND OBJECTIVE: Local PUVA (psoralen plus UVA light) is an effective outpatient treatment for patients with palmoplantar eczema or psoriasis. In this study, the efficacy, applicability and patient acceptance of two local forms of 8-methoxypsoralen (8-MOP) PUVA therapy were compared. METHODS: The study design was a left-right comparison (n = 37): the left hand or foot was treated with (aqueous) 8-MOP bath PUVA whereas the right received (ethanolic) 8-MOP lotion PUVA. After 1 month, the more successful treatment was continued on both sides until lesions cleared. RESULTS: Both therapies were effective and both useful for particular clinical applications: patients with erosive lesions and rhagades appreciated the gentleness of bath PUVA. Those with pustules or hyperkeratotic lesions appreciated the greater effectiveness of 8-MOP lotion PUVA. The total UVA dose and number of sessions to clearance were smaller with 8-MOP lotion. There was no difference in the length of the relapse-free period. Therapy nonresponders usually became apparent within the first 12 sessions. CONCLUSIONS: The difference between bath PUVA and lotion PUVA can be described as 'gentle' versus 'strong' therapy. The better therapy depends on clinical indication.
Mots-clé
Administration, Cutaneous Adult Baths Dose-Response Relationship, Drug Female Foot Dermatoses/*drug therapy Hand Dermatoses/*drug therapy Humans Male Methoxsalen/*administration & dosage Middle Aged *PUVA Therapy Photosensitizing Agents/*administration & dosage Psoriasis/*drug therapy Treatment Outcome
Pubmed
Web of science
Création de la notice
25/01/2008 16:55
Dernière modification de la notice
20/08/2019 12:51
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