Wernicke's encephalopathy with ballooned neurons in the mamillary bodies: an immunohistochemical study1

Détails

ID Serval
serval:BIB_1A4C1E45F357
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Wernicke's encephalopathy with ballooned neurons in the mamillary bodies: an immunohistochemical study1
Périodique
Neuropathology and Applied Neurobiology
Auteur(s)
Freiesleben  W., Soylemezoglu  F., Lowe  J., Janzer  R. C., Kleihues  P.
ISSN
0305-1846 (Print)
Statut éditorial
Publié
Date de publication
1997
Volume
23
Numéro
1
Pages
36-42
Notes
PT - Case Reports PT - Journal Article
Résumé
Two cases of Wernicke's encephalopathy with the rare phenomenon of ballooned neurons in the mamillary bodies are reported. Both patients suffered from acute Wernicke's symptoms starting approximately two weeks before death. The mamillary bodies contained grossly enlarged, ballooned neurons, in one case associated with focal necrosis. The affected neurons were immunoreactive for phosphorylated neurofilament (160 and 200 kDa), and synaptophysin. Ubiquitin and alpha beta-crystallin expression were not detected. The mamillo-thalamic tract appeared normal in both cases. There was a marked associated microglial reaction, as shown by the antibody Ki-MIP. It is concluded that the ballooning of mamillary neurons reflects an acute retrograde reaction to primarily axonal damage. Rather than being a rare manifestation of the disease, these cases may constitute a typical intermediate early stage (10-15 days) in the development of Wernicke's encephalopathy)
Mots-clé
Humans/Immunohistochemistry/Male/Mamillary Bodies/metabolism/Pathology/Middle Aged/Wernicke Encephalopathy
Pubmed
Web of science
Création de la notice
29/01/2008 19:36
Dernière modification de la notice
03/03/2018 14:28
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