Regulation of microtubule dynamics by the neuronal growth-associated protein SCG10.

Details

Serval ID
serval:BIB_1A29A39973DE
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Regulation of microtubule dynamics by the neuronal growth-associated protein SCG10.
Journal
Proceedings of the National Academy of Sciences of the United States of America
Author(s)
Riederer B.M., Pellier V., Antonsson B., Di Paolo G., Stimpson S.A., Lütjens R., Catsicas S., Grenningloh G.
ISSN
0027-8424 (Print)
ISSN-L
0027-8424
Publication state
Published
Issued date
1997
Volume
94
Number
2
Pages
741-745
Language
english
Abstract
Dynamic assembly and disassembly of microtubules is essential for cell division, cell movements, and intracellular transport. In the developing nervous system, microtubule dynamics play a fundamental role during neurite outgrowth, elongation, and branching, but the molecular mechanisms involved are unknown. SCG10 is a neuron-specific protein that is membrane-associated and highly enriched in growth cones. Here we show that SCG10 binds to microtubules, inhibits their assembly, and can induce microtubule disassembly. We also show that SCG10 overexpression enhances neurite outgrowth in a stably transfected neuronal cell line. These data identify SCG10 as a key regulator of neurite extension through regulation of microtubule instability.
Keywords
Animals, Carrier Proteins, Cell Differentiation, Fluorescent Antibody Technique, Indirect, Light, Macromolecular Substances, Membrane Proteins, Microtubules/physiology, Nerve Growth Factors/physiology, Nerve Tissue Proteins/physiology, Neurites/ultrastructure, PC12 Cells, Rats, Scattering, Radiation, Swine, Tubulin/physiology
Pubmed
Web of science
Open Access
Yes
Create date
24/01/2008 14:34
Last modification date
20/08/2019 12:51
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