Pharmacology of converting enzyme inhibitors

Détails

ID Serval
serval:BIB_19BECDD29A7F
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Pharmacology of converting enzyme inhibitors
Périodique
Clinical and Experimental Hypertension. Part A, Theory and Practice
Auteur(s)
Brunner  H. R., Waeber  B., Nussberger  J.
ISSN
1064-1963
0730-0077 (Print)
Statut éditorial
Publié
Date de publication
1987
Volume
9
Numéro
2-3
Pages
275-88
Notes
Journal Article
Review
Résumé
Angiotensin converting enzyme inhibitors were developed to prevent the in vivo generation of angiotensin II and thereby to reduce peripheral vasoconstriction. However, these compounds exert some additional effects that may or may not be angiotensin dependent. These include potential sodium diuresis, bradykinin accumulation, prostaglandin release, blunting of sympathetic activity, parasympathomimetic actions, central effects, redistribution of blood flow toward some particularly important organs. Only the comprehensive assessment of the many complex interactions that exist between the renin-angiotensin and several other regulatory systems reveals the complete therapeutic profile of this class of pharmacologic agents.
Mots-clé
*Angiotensin-Converting Enzyme Inhibitors Animals Antihypertensive Agents/adverse effects Hemodynamic Processes/drug effects Humans
Pubmed
Web of science
Création de la notice
05/03/2008 17:40
Dernière modification de la notice
03/03/2018 14:27
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