A functional neuroanatomy of tics in Tourette syndrome.

Details

Serval ID
serval:BIB_18EB43DFEC40
Type
Article: article from journal or magazin.
Collection
Publications
Title
A functional neuroanatomy of tics in Tourette syndrome.
Journal
Archives of General Psychiatry
Author(s)
Stern E., Silbersweig D.A., Chee K.Y., Holmes A., Robertson M.M., Trimble M., Frith C.D., Frackowiak R.S., Dolan R.J.
ISSN
0003-990X (Print)
ISSN-L
0003-990X
Publication state
Published
Issued date
2000
Volume
57
Number
8
Pages
741-748
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
Background: Ties are involuntary, brief, stereotyped motor and vocal behaviors often associated with irresistible urges. They are a defining symptom of the classic neuropsychiatric disorder, Tourette syndrome (TS), and constitute an example of disordered human volition. The neural correlates of ties are not well understood and have not been imaged selectively.
Methods: Event-related [(15)O]H(2)O positron emission tomography techniques combined with time-synchronized audio and videotaping were used to determine the duration of, frequency of, and radiotracer input during ties in each of 72 scans from 6 patients with TS. This permitted a voxel-by-voxel correlational analysis within Statistical Parametric Mapping of patterns of neural activity associated with the ties.
Results: Brain regions in which activity was significantly correlated with tic occurrence in the group included medial and lateral premotor cortices, anterior cingulate cortex, dorsolateral-rostral prefrontal cortex, inferior parietal cortex, putamen, and caudate, as well as primary motor cortex, the Broca's area, superior temporal gyrus, insula, and claustrum. In an individual patient with prominent coprolalia? such vocal ties were associated with activity in prerolandic and postrolandic language regions, insula, caudate, thalamus, and cerebellum, while activity in sensorimotor cortex was noted with motor ties.
Conclusions: Aberrant activity in the interrelated sensorimotor, language, executive, and paralimbic circuits identified in this study may account for the initiation and execution of diverse motor and vocal behaviors that characterize ties in TS, as well as for the urges that often accompany them.
Keywords
Adult, Brain/physiopathology, Brain/radionuclide imaging, Brain Mapping, Humans, Male, Middle Aged, Motor Cortex/physiopathology, Motor Cortex/radionuclide imaging, Oxygen Radioisotopes/diagnostic use, Prefrontal Cortex/physiopathology, Prefrontal Cortex/radionuclide imaging, Severity of Illness Index, Speech/physiology, Stereotaxic Techniques, Stereotypic Movement Disorder/diagnosis, Stereotypic Movement Disorder/physiopathology, Tape Recording/statistics & numerical data, Tics/physiopathology, Tomography, Emission-Computed/statistics & numerical data, Tourette Syndrome/diagnosis, Tourette Syndrome/physiopathology
Pubmed
Web of science
Open Access
Yes
Create date
12/09/2011 19:50
Last modification date
20/08/2019 12:49
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