The ubiquitin-proteasome system in prostate cancer and its transition to castration resistance.

Details

Serval ID
serval:BIB_1811F8DC7D58
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
The ubiquitin-proteasome system in prostate cancer and its transition to castration resistance.
Journal
Urologic Oncology
Author(s)
Voutsadakis I.A., Papandreou C.N.
ISSN
1873-2496 (Electronic)
ISSN-L
1078-1439
Publication state
Published
Issued date
2012
Volume
30
Number
6
Pages
752-761
Language
english
Notes
Publication types: Journal Article ; Review
Abstract
Prostate cancer is the most common carcinoma in the male population. In its initial stage, the disease is androgen-dependent and responds therapeutically to androgen deprivation treatment but it usually progresses after a few years to an androgen-independent phase that is refractory to hormonal manipulations. The proteasome is a multi-unit protease system that regulates the abundance and function of a significant number of cell proteins, and its inhibition results in cancer cell growth inhibition and apoptosis and is already exploited in the clinic with the use of proteasome inhibitor bortezomib in multiple myeloma. In order to be recognized by the proteasome, a target protein needs to be linked to a chain of the small protein ubiquitin. In this paper, we review the role of ubiquitin-proteasome system (UPS) in androgen receptor-dependent transcription as well as in the castration resistant stage of the disease, and we discuss therapeutic opportunities that UPS inhibition offers in prostate cancer.
Keywords
Androgen Antagonists/therapeutic use, Antineoplastic Agents, Hormonal/therapeutic use, Drug Resistance, Neoplasm/physiology, Humans, Male, Prostatic Neoplasms/metabolism, Prostatic Neoplasms/physiopathology, Proteasome Endopeptidase Complex/metabolism, Ubiquitin/metabolism
Pubmed
Web of science
Create date
25/08/2010 13:16
Last modification date
20/08/2019 12:48
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