Expression of MHC class II molecules contributes to lipopolysaccharide responsiveness.

Details

Serval ID
serval:BIB_17431
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Expression of MHC class II molecules contributes to lipopolysaccharide responsiveness.
Journal
European Journal of Immunology
Author(s)
Piani A., Hossle J.P., Birchler T., Siegrist C.A., Heumann D., Davies G., Loeliger S., Seger R., Lauener R.P.
ISSN
0014-2980
Publication state
Published
Issued date
2000
Volume
30
Number
11
Pages
3140-3146
Language
english
Notes
Publication types: Journal Article
Abstract
Activation of phagocytes by lipopolysaccharide (LPS) causes synthesis and secretion of various mediators of inflammation. CD14, a glycosylphosphatidylinositol-anchored monocytic antigen serving as receptor for LPS, and members of the family of Toll-like receptors mediate cellular activation in response to LPS. Here we investigated whether expression of MHC class II molecules modified the response to LPS. Comparing LPS responsiveness of human and murine cells differing for expression of MHC class II molecules, we found that lack or a low level of expression of MHC class II molecules resulted in diminished secretion of pro-inflammatory cytokines following stimulation with LPS. Thus, expression of MHC class II molecules modifies LPS responsiveness, a finding suggesting that these molecules contribute to the pathogenesis not only of exotoxin-triggered toxic shock but also of endotoxin-triggered septic shock. Additionally to their role in antigen-specific immunity MHC class II molecules may influence the inflammatory response triggered by microbial constituents.
Keywords
Animals, Histocompatibility Antigens Class II/immunology, Humans, Immunity, Innate, Lipopolysaccharides/immunology, Mice, Mice, Knockout
Pubmed
Web of science
Create date
19/11/2007 12:11
Last modification date
20/08/2019 12:47
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