High tPA-expression in primary melanoma of the limb correlates with good prognosis.

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Serval ID
serval:BIB_17066
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
High tPA-expression in primary melanoma of the limb correlates with good prognosis.
Journal
British Journal of Cancer
Author(s)
Ferrier C.M., Suciu S., van Geloof W.L., Straatman H., Eggermont A.M., Koops H.S., Kroon B.B., Lejeune F.J., Kleeberg U.R., van Muijen G.N., Ruiter D.J.
ISSN
0007-0920
Publication state
Published
Issued date
2000
Peer-reviewed
Oui
Volume
83
Number
10
Pages
1351-1359
Language
english
Abstract
To investigate whether the course of primary melanoma disease correlates with expression of the various components of the proteolytic plasminogen activation (PA) system, immunohistochemical stainings for activators of plasminogen (tissue type (tPA) and urokinase type (uPA)), inhibitors of plasminogen activation (type 1 (PAI-1) and type 2 (PAI-2)) and the receptor for uPA (uPAR) were performed on 214 routinely processed melanoma lesions. All lesions were primary cutaneous melanomas, minimally 1.5 mm thick, and derived from patients with only local disease at the moment of diagnosis (clinically stage II (T(3-4)N(0)M(0)), American Joint Committee on Cancer). Median patient follow-up was 6.1 years. Single variables as immunohistochemical staining results (extent of tumour cell staining, pattern of tumour cell staining and for some components also staining of stromal cells), histopathological and clinical parameters as well as treatment variables were analysed in order to assess their prognostic importance, in terms of time to recurrence, time to distant metastasis and duration of survival. The extent of tPA tumour cell positivity, categorized as 0-5%, 6-50% and 51-100%, appeared to be of importance for these end-points. Lesions with 51-100% tPA-positive tumour cells were found to have the best prognosis, whereas lesions with 6-50% tPA-positive tumour cells had the worst. Moreover, the prognostic significance of Breslow thickness, microscopic ulceration and sex was confirmed in this study. Multivariate analyses, incorporating these relevant factors, showed that the extent of tPA tumour cell positivity was an independent prognostic factor for distant metastasis-free interval (P = 0.012) and for the duration of survival (P = 0.043).
Keywords
Adolescent, Adult, Aged, Disease-Free Survival, Extremities, Female, Follow-Up Studies, Humans, Immunohistochemistry, Male, Melanoma/chemistry, Melanoma/pathology, Middle Aged, Neoplasm Invasiveness, Neoplasm Staging, Predictive Value of Tests, Prognosis, Sensitivity and Specificity, Skin Neoplasms/chemistry, Skin Neoplasms/pathology, Tissue Plasminogen Activator/analysis, Urokinase-Type Plasminogen Activator/analysis
Pubmed
Web of science
Open Access
Yes
Create date
19/11/2007 12:10
Last modification date
20/08/2019 12:46
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