Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Clinical genetics of Parkinson's disease and related disorders.
Parkinsonism and Related Disorders
13 Suppl 3
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
Our knowledge regarding the genetics of Parkinson's disease (PD) and parkinsonism has evolved dramatically during the past decade, with the discovery of numerous loci and genes. The LRRK2 gene has emerged as the most commonly involved in both familial and sporadic PD. Several variants in LRRK2 and SNCA have been associated with an increased risk of sporadic PD. PRKN, PINK1 and DJ1 mutations cause early-onset recessively inherited PD. Autosomal dominant dementia and parkinsonism is caused by mutations in the MAPT gene, and in the most recently discovered PGRN gene.
Genetic Predisposition to Disease/genetics, Humans, Intercellular Signaling Peptides and Proteins/genetics, Intracellular Signaling Peptides and Proteins/genetics, Mutation, Oncogene Proteins/genetics, Parkinson Disease/genetics, Parkinson Disease/pathology, Parkinsonian Disorders/genetics, Parkinsonian Disorders/pathology, Protein-Serine-Threonine Kinases/genetics, Ubiquitin-Protein Ligases/genetics, alpha-Synuclein/genetics, tau Proteins/genetics
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