Estrogen receptor regulates MyoD gene expression by preventing AP-1-mediated repression.

Details

Serval ID
serval:BIB_157D627D2D9A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Estrogen receptor regulates MyoD gene expression by preventing AP-1-mediated repression.
Journal
Biochemical and Biophysical Research Communications
Author(s)
Pedraza-Alva G., Zingg J.M., Donda A., Pérez-Martínez L.
ISSN
1090-2104[electronic]
Publication state
Published
Issued date
2009
Volume
389
Number
2
Pages
360-365
Language
english
Abstract
Cell growth and differentiation are opposite events in the myogenic lineage. Growth factors block the muscle differentiation program by inducing the expression of transcription factors that negatively regulate the expression of muscle regulatory genes like MyoD. In contrast, extracellular clues that induce cell cycle arrest promote MyoD expression and muscle differentiation. Thus, the regulation of MyoD expression is critical for muscle differentiation. Here we show that estrogen induces MyoD expression in mouse skeletal muscle in vivo and in dividing myoblasts in vitro by relieving the MyoD promoter from AP-1 negative regulation through a mechanism involving estrogen receptor/AP-1 protein-protein interactions but independent of the estrogen receptor DNA binding activity.
Keywords
Animals, Estrogens/metabolism, Estrogens/pharmacology, Gene Expression Regulation, JNK Mitogen-Activated Protein Kinases/metabolism, Mice, Muscle Development/genetics, MyoD Protein/genetics, Myoblasts, Skeletal/drug effects, Myoblasts, Skeletal/metabolism, Proto-Oncogene Proteins c-fos/metabolism, Receptors, Estrogen/metabolism, Transcription Factor AP-1/metabolism, Transcription, Genetic/drug effects
Pubmed
Web of science
Create date
29/10/2009 10:10
Last modification date
20/08/2019 12:44
Usage data