Article: article from journal or magazin.
Selective bystander proliferation of memory CD4+ and CD8+ T cells upon NK T or T cell activation.
Journal of Immunology
Ag-experienced or memory T cells have increased reactivity to recall Ag, and can be distinguished from naive T cells by altered expression of surface markers such as CD44. Memory T cells have a high turnover rate, and CD8(+) memory T cells proliferate upon viral infection, in the presence of IFN-alphabeta and/or IL-15. In this study, we extend these findings by showing that activated NKT cells and superantigen-activated T cells induce extensive bystander proliferation of both CD8(+) and CD4(+) memory T cells. Moreover, proliferation of memory T cells can be induced by an IFN-alphabeta-independent, but IFN-gamma- or IL-12-dependent pathway. In these conditions of bystander activation, proliferating memory (CD44(high)) T cells do not derive from activation of naive (CD44(low)) T cells, but rather from bona fide memory CD44(high) T cells. Together, these data demonstrate that distinct pathways can induce bystander proliferation of memory T cells.
Animals, Antigens, CD44/biosynthesis, CD4-Positive T-Lymphocytes/cytology, CD4-Positive T-Lymphocytes/drug effects, CD8-Positive T-Lymphocytes/cytology, CD8-Positive T-Lymphocytes/drug effects, Cell Differentiation/drug effects, Cell Differentiation/immunology, Cell Division/drug effects, Cell Division/immunology, Epitopes, T-Lymphocyte/immunology, Female, Galactosylceramides/pharmacology, HLA-C Antigens/biosynthesis, HLA-C Antigens/genetics, Humans, Immunologic Memory/drug effects, Killer Cells, Natural/drug effects, Killer Cells, Natural/immunology, Lymphocyte Activation/drug effects, Mast-Cell Sarcoma, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Inbred DBA, Mice, Knockout, T-Lymphocyte Subsets/cytology, T-Lymphocyte Subsets/drug effects, Tumor Cells, Cultured/transplantation
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