Effect of exercise on the leg distribution of C15O2 and 15O2 in normals and in patients with peripheral ischemia: a study using positron tomography

Details

Serval ID
serval:BIB_14E1782C567A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Effect of exercise on the leg distribution of C15O2 and 15O2 in normals and in patients with peripheral ischemia: a study using positron tomography
Journal
International Angiology
Author(s)
Depairon  M., De Landsheere  C., Merlo  P., Del Fiore  G., Quaglia  L., Peters  J. M., Lamotte  D., Zicot  M.
ISSN
0392-9590 (Print)
Publication state
Published
Issued date
09/1988
Volume
7
Number
3
Pages
254-7
Notes
Comparative Study
Journal Article --- Old month value: Jul-Sep
Abstract
In order to evaluate regional muscle blood flow and oxygen utilization, we study with positron emission tomography (PET) the distribution of C15O2 and 15O2 in 17 subjects: 5 normals (24 +/- 3 years) and 12 patients (63 +/- 13.5 years). C15O2 and 15O2 are inhalated with a steady-state technique. Positron tomograms are recorded in supine position at the greatest diameter of the leg. Exercise consists in simultaneous ankle flexions. In all normals, C15O2 and 15O2 are distributed homogeneously and symmetrically in both legs. At rest, they concentrate in the region of vascular pedicle. After exercise, C15O2 and 15O2 are electively distributed in the anterolateral region of the leg. In patients, this pattern of distribution is similar but asymmetrical. Moreover, the regional uptake of C15O2 and 15O2 often dissociates. In conclusion, C15O2 and 15O2 allow to study repeatedly muscle blood flow and oxygen utilization in patients with peripheral ischemia, both at rest and after exercise. The broad spectrum of pathological changes observed in this study needs further metabolic investigations.
Keywords
Adult Arterial Occlusive Diseases/physiopathology/*radionuclide imaging Carbon Radioisotopes/diagnostic use *Exertion Female Humans Leg/*blood supply Male Middle Aged Muscles/*blood supply Oxygen Consumption Oxygen Radioisotopes/diagnostic use Regional Blood Flow *Tomography, Emission-Computed
Pubmed
Web of science
Create date
17/01/2008 16:33
Last modification date
20/08/2019 12:43
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