Activation of metabotropic glutamate receptors delays apoptosis of chick embryonic motor neurons in vitro.

Details

Serval ID
serval:BIB_141199987A19
Type
Article: article from journal or magazin.
Collection
Publications
Title
Activation of metabotropic glutamate receptors delays apoptosis of chick embryonic motor neurons in vitro.
Journal
Neuroreport
Author(s)
Anneser J.M., Horstmann S., Weydt P., Borasio G.D.
ISSN
0959-4965 (Print)
ISSN-L
0959-4965
Publication state
Published
Issued date
1998
Volume
9
Number
9
Pages
2039-2043
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
Glutamatergic excitotoxicity has been implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS). However, activation of metabotropic glutamate receptors (mGluRs) is neuroprotective in several paradigms. We therefore tested the effect of selective mGluR agonists on cultured chick embryonic motor neurons. Activation of group I mGluRs with (s)-3,5-dihydroxyphenylglycine (DHPG) and group III mGluRs with L-2-amino-4-phosphono-butanoate (L-AP4) promoted a modest but significant, dose-dependent delay of apoptosis, which could be blocked by specific mGluR antagonists. Group II or selective mGluR5 stimulations were ineffective. Correspondingly, in situ hybridization experiments showed only expression of mGluR1 (group I) and mGluR4 and 7 (group III) in human motor neurons. Dissection of the pathways involved in this survival effect may help to elucidate the pathogenesis of ALS.
Keywords
Animals, Apoptosis/drug effects, Cell Count, Cell Survival/drug effects, Cells, Cultured, Chick Embryo, Excitatory Amino Acid Agonists/pharmacology, Humans, In Situ Hybridization, Motor Neurons/drug effects, Receptors, Metabotropic Glutamate/agonists, Receptors, Metabotropic Glutamate/metabolism, Spinal Cord/drug effects, Spinal Cord/metabolism
Pubmed
Web of science
Create date
13/01/2014 16:58
Last modification date
20/08/2019 12:42
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