In utero exposure to immunosuppressive drugs.

Details

Serval ID
serval:BIB_12B807E65B9C
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
In utero exposure to immunosuppressive drugs.
Journal
Biology of the Neonate
Author(s)
Prévot A., Martini S., Guignard J.P.
ISSN
0006-3126
Publication state
Published
Issued date
2002
Peer-reviewed
Oui
Volume
81
Number
2
Pages
73-81
Language
english
Notes
Publication types: Journal Article ; Review
Abstract
The number of pregnant women receiving immunosuppressants for anti-rejection therapy or autoimmune diseases is increasing. All immunosuppressive drugs cross the placenta, raising questions about the long-term outcome of the children exposed in utero. There is no higher risk of congenital anomalies. However, an increased incidence of prematurity, intrauterine growth retardation (IUGR) and generally low birth weight has been reported, as well as maternal hypertension and preeclampsia. The most frequent neonatal complications are those associated with prematurity and IUGR, as well as adrenal insufficiency with corticosteroids, immunological disturbances with azathioprine and cyclosporine, and hyperkalemia with tacrolimus. The long-term follow-up of infants exposed to immunosuppressants in utero is still limited and experimental studies raise the question whether there could be an increased incidence at adult age of some pathologies including renal insufficiency, hypertension and diabetes.
Keywords
Female, Fetal Growth Retardation, Humans, Immunosuppressive Agents/adverse effects, Immunosuppressive Agents/pharmacokinetics, Infant, Low Birth Weight, Infant, Newborn, Infant, Premature, Male, Maternal-Fetal Exchange/physiology, Pregnancy
Pubmed
Web of science
Create date
20/07/2009 13:31
Last modification date
20/08/2019 12:40
Usage data