Article: article from journal or magazin.
Growth and pubertal development in five boys with Noonan's syndrome
Archives of Disease in Childhood
Journal Article --- Old month value: Jan
Five boys, each with at least 4 features characteristic of Noonan's syndrome, were studied throughout childhood. In each the height was on or below the 3rd centile. Height velocity was essentially normal during the prepubertal period whereas bone age and pubertal development were delayed. Four boys had cryptorchidism and in 2 no testicular enlargement or spontaneous puberty occurred, necessitating testosterone replacement. Plasma concentrations of luteinising hormone and follicle-stimulating hormone before and after stimulation with luteinising hormone-releasing hormone were increased in 4 of the boys. These findings are consistent with primary gonadal failure associated with impaired spermatogenesis.
Adolescent Child Cryptorchidism/complications Follicle Stimulating Hormone/blood *Growth Humans Luteinizing Hormone/blood Male Noonan Syndrome/complications/*physiopathology *Puberty Testis/physiopathology Testosterone/blood
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