Article: article from journal or magazin.
Downstream targets of let-60 Ras in Caenorhabditis elegans.
In Caenorhabditis elegans, let-60 Ras controls many cellular processes, such as differentiation of vulval epithelial cells, function of chemosensory neurons, and meiotic progression in the germ line. Although much is known about the let-60 Ras signaling pathway, relatively little is understood about the target genes induced by let-60 Ras signaling that carry out terminal effector functions leading to morphological change. We have used DNA microarrays to identify 708 genes that change expression in response to activated let-60 Ras.
Animals, Caenorhabditis elegans/embryology, Caenorhabditis elegans/genetics, Caenorhabditis elegans Proteins, Gene Expression Regulation, Developmental, Helminth Proteins/genetics, Oligonucleotide Array Sequence Analysis, Signal Transduction/genetics, ras Proteins/genetics
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