2D-spatially-selective real-time magnetic resonance imaging for the assessment of microvascular function and its relation to the cardiovascular risk profile.

Détails

ID Serval
serval:BIB_11150AD3128B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
2D-spatially-selective real-time magnetic resonance imaging for the assessment of microvascular function and its relation to the cardiovascular risk profile.
Périodique
Journal of Cardiovascular Magnetic Resonance
Auteur(s)
Schwitter J., Oelhafen M., Wyss B.M., Kozerke S., Amann-Vesti B., Lüscher T.F., Boesiger P.
ISSN
1097-6647 (Print)
ISSN-L
1097-6647
Statut éditorial
Publié
Date de publication
2006
Volume
8
Numéro
5
Pages
759-769
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Validation Studies
Publication Status: ppublish
Résumé
BACKGROUND: While local endothelial dysfunction of conduit arteries is well recognized as an early step in atherogenesis, contradictory observations are reported with regard to alterations in the microcirculation and their association with cardiovascular risk factors (RFs). A real-time MR approach was developed to investigate the relationship between the RFs profile and microcirculatory alterations assessed as impairment of reactive hyperemic flow in the leg circulation.
METHODS: The MR technique was applied to patients (n = 17, Pats1) with 1.8 +/- 0.8 RFs but without peripheral arterial occlusive disease (PAD), to age-matched healthy controls (n = 13, Con1), to young controls (n = 12, 23 +/- 4 y), and to patients with RFs and PAD (n = 8, Pats2).
RESULTS: Superficial femoral artery (SFA) peak hyperemic flow in Pats1 was reduced vs Con1 (24.6 +/- 4.2 vs 30.4 +/- 7.3 mL min-1 100 mL-1 calf tissue, p < 0.02), and minimal vascular resistance increased incrementally with the number of RFs and with Framingham and Procam risk scores. Flow-mediated vasodilation (FMD) of the SFA was blunted in both Pats1 and Con1 (-0.5 +/- 3.4% and +0.6 +/- 3.2%, respectively, both ns vs 0). In young controls, peak hyperemic flow (30.1 +/- 3.3 mL min-1. 100 mL-1) and endothelium-independent vasodilation (9.2 +/- 10.0%) were preserved, while FMD was minimal (2.0 +/- 5.9%,p < 0.02 vs endothelium-independent vasodilation). In Pats2, peak hyperemic flow was severely reduced (12.2 +/- 3.6 mL min-1 100 mL-1, p < 0.0003 vs Con1 and Pats1), and both FMD and endothelium-independent vasodilation were absent.
CONCLUSIONS: Reactive hyperemic flow in the SFA, reflecting microcirculatory function of the lower limb, gradually decreases with increasing cardiovascular risk suggesting a role for microvascular dysfunction in atherogenesis. The presented MR approach might become a valuable tool to study (micro)-vascular pathophysiology.
Mots-clé
Adult, Aged, Biological Markers/blood, Blood Flow Velocity, Cardiovascular Diseases/physiopathology, Case-Control Studies, Computer Systems, Endothelium, Vascular/physiopathology, Female, Femoral Artery/physiopathology, Humans, Hyperemia/physiopathology, Leg/blood supply, Magnetic Resonance Imaging, Male, Microcirculation, Middle Aged, Observer Variation, Pulsatile Flow, Regional Blood Flow, Reproducibility of Results, Research Design, Risk Assessment, Risk Factors, Stroke Volume, Vascular Resistance, Vasodilation
Pubmed
Web of science
Création de la notice
07/09/2011 18:09
Dernière modification de la notice
20/08/2019 13:38
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