Review article: platelet-collagen interactions: membrane receptors and intracellular signalling pathways.
Details
Serval ID
serval:BIB_0F602378FE75
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Review article: platelet-collagen interactions: membrane receptors and intracellular signalling pathways.
Journal
European Journal of Clinical Investigation
ISSN
0014-2972 (Print)
ISSN-L
0014-2972
Publication state
Published
Issued date
1999
Peer-reviewed
Oui
Volume
29
Number
12
Pages
1066-1076
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. ; Review Publication Status: ppublish
Abstract
Platelet adhesion to and activation by exposed subendothelial collagen plays a critical role in normal haemostasis and pathological thrombosis. Recent advances in elucidating the mechanisms underlying platelet-collagen interaction support a 'two-site, two-step' model. Direct platelet binding to integrin alpha2beta1 mainly sustains adhesion and allows recognition of glycoprotein VI. The latter interaction is responsible for characteristic intracellular signalling events leading to p72Syk and PLCgamma2 activation. The present review describes the known collagen receptors on platelets and discusses the current understanding of signal transduction promoted by collagen.
Keywords
Blood Platelets/metabolism, Collagen/metabolism, Humans, Integrins/metabolism, Receptors, Cell Surface, Receptors, Collagen, Signal Transduction
Pubmed
Web of science
Create date
10/02/2015 12:19
Last modification date
20/08/2019 13:36
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