Uterine contractions at the time of embryo transfer alter pregnancy rates after in-vitro fertilization

Details

Serval ID
serval:BIB_0F5EB5685640
Type
Article: article from journal or magazin.
Collection
Publications
Title
Uterine contractions at the time of embryo transfer alter pregnancy rates after in-vitro fertilization
Journal
Human Reproduction
Author(s)
Fanchin  R., Righini  C., Olivennes  F., Taylor  S., de Ziegler  D., Frydman  R.
ISSN
0268-1161
Publication state
Published
Issued date
07/1998
Peer-reviewed
Oui
Volume
13
Number
7
Pages
1968-74
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jul
Abstract
To investigate the possible consequences of uterine contractions (UC) as visualized by ultrasound (US) on in-vitro fertilization (IVF)-embryo transfer outcome, we studied prospectively 209 infertile women undergoing 220 cycles of controlled ovarian stimulation. Inclusion criteria were age < or = 38 years, a morphologically normal uterus, and at least three good quality embryos transferred. Just before embryo transfer, women underwent 5 min digital recordings of the uterus using US image analysis software for UC assessment. Plasma progesterone and oestradiol concentrations were measured. Four groups were defined according to UC frequency: < or = 3.0 (n = 53), 3.1-4.0 (n = 50), 4.1-5.0 (n = 43), and > 5.0 (n = 74) UC/min respectively. Patients, controlled ovarian hyperstimulation and embryology characteristics were comparable in all groups. A stepwise decrease in clinical and ongoing pregnancy rates as well as in implantation rates occurred from the lowest to the highest UC frequency groups (53, 36, 21; 46, 32, 20; 23, 19, 10; and 14, 11, 4%; P < 0.001). Plasma progesterone and UC frequency were negatively correlated (r = -0.34, P < 0.001). Direction of UC did not affect embryo transfer outcome. As this study was controlled strictly for confounding variables and UC were assessed objectively by a computerized system, its results indicate that high frequency UC on the day of embryo transfer hinder IVF-embryo transfer outcome, possibly by expelling embryos out of the uterine cavity. The negative correlation between UC frequency and progesterone concentrations supports the uterine relaxing properties of progesterone.
Keywords
Chorionic Gonadotropin/administration & dosage *Embryo Transfer Estradiol/blood Female *Fertilization in Vitro Follicle Stimulating Hormone/blood Humans Menotropins/administration & dosage Ovulation Induction Pregnancy Progesterone/blood Prospective Studies *Uterine Contraction Uterus/ultrasonography
Pubmed
Web of science
Open Access
Yes
Create date
28/02/2008 11:36
Last modification date
20/08/2019 12:36
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