Fully-automated systems and the need for global approaches should exhort clinical labs to reinvent routine MS analysis?

Details

Serval ID
serval:BIB_0E23CCB1FA7F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Fully-automated systems and the need for global approaches should exhort clinical labs to reinvent routine MS analysis?
Journal
Bioanalysis
Author(s)
Rochat B.
ISSN
1757-6199 (Electronic)
ISSN-L
1757-6180
Publication state
Published
Issued date
01/07/2018
Peer-reviewed
Oui
Volume
10
Number
14
Pages
1129-1141
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Today, many LC-high-resolution MS instruments have become affordable, easy-to-use, sensitive and quantitative. Meanwhile, there is an increased need for more comprehensive approaches. However, omics analyses are still restricted to specialists whereas, in hospitals, routine analyses are targeted and quantitative and represent the main and heavy tasks. But the availability of fully automated LC-MS instruments that can handle independently from sample extraction to result reporting, as well as the increasing biomedical interest for global approaches, clinical analytical workflow should be reorganized. Bioanalysts are now in the position to develop/implement clinical metabolomics or proteomics as routine analyses. In this article, this coming evolution and the reasons to implement global/omics determinations as routine analysis, is described.
Keywords
Automation/economics, Chromatography, Liquid/economics, Clinical Laboratory Techniques/economics, Humans, Mass Spectrometry/economics, Metabolomics, Methadone/blood, Proteomics, Testosterone/blood, LC–MS, LDT, automation, clinical metabolomics, clinical proteomics, high-resolution mass spectrometry (HRMS), laboratory developed tests
Pubmed
Web of science
Create date
18/07/2018 14:30
Last modification date
21/08/2019 5:33
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