Activation of the thromboxane A2 pathway in human prostate cancer correlates with tumor Gleason score and pathologic stage.

Détails

ID Serval
serval:BIB_0D7BEC7C225C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Activation of the thromboxane A2 pathway in human prostate cancer correlates with tumor Gleason score and pathologic stage.
Périodique
European Urology
Auteur(s)
Dassesse T., de Leval X., de Leval L., Pirotte B., Castronovo V., Waltregny D.
ISSN
0302-2838[print], 0302-2838[linking]
Statut éditorial
Publié
Date de publication
2006
Volume
50
Numéro
5
Pages
1021-31; discussion 1031
Langue
anglais
Résumé
OBJECTIVE: We investigated the potential involvement of the thromboxane A(2) (TXA(2)) pathway in human prostate cancer (PCa). METHODS: Expression of cyclooxygenase-2 (COX-2), TXA(2) synthase (TXS), and TXA(2) receptors (TPRs), the main actors of the TXA(2) pathway, was analyzed on serial tissue sections from 46 human PCa specimens. RESULTS: The expression levels of COX-2, TXS, and TPRs were significantly higher in malignant than in corresponding nontumoral prostatic epithelial cells. Increased immunoreactivity for these antigens was also observed in high-grade prostate intraepithelial neoplasia (HGPIN) glands. COX-2, TXS, and TPR proteins usually displayed a coordinated overexpression pattern in PCa lesions, as assessed in serial tissue sections. Increased levels of these proteins in the tumors were all significantly associated with higher Gleason scores and pathologic stages. CONCLUSIONS: Proteins specifically involved in the TXA(2) pathway are up-regulated in human PCa and their level of expression is associated with tumor extraprostatic extension and loss of differentiation. Our study is the first to examine simultaneously all key proteins involved in this pathway including TXA(2) receptors and results suggest that the TXA(2) pathway may be a potential target for PCa prevention/therapy.
Mots-clé
Aged, Cell Differentiation, Cyclooxygenase 2/metabolism, Gene Expression, Humans, Male, Membrane Proteins/metabolism, Middle Aged, Neoplasm Staging, Prostatic Neoplasms/pathology, Protein Transport, Receptors, Thromboxane/metabolism, Thromboxane A2/metabolism, Thromboxane-A Synthase/metabolism
Pubmed
Création de la notice
27/10/2010 10:05
Dernière modification de la notice
03/03/2018 13:40
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