Prognostic risk factors of survival after resection of hepatocellular carcinoma.

Détails

ID Serval
serval:BIB_0D626629D0CF
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Prognostic risk factors of survival after resection of hepatocellular carcinoma.
Périodique
Hepato-gastroenterology
Auteur(s)
Hubert C., Sempoux C., Rahier J., Horsmans Y., Geubel A., Van Beers B.E., Annet L., Zech F., Leonard D., Gigot J.F.
ISSN
0172-6390 (Print)
ISSN-L
0172-6390
Statut éditorial
Publié
Date de publication
2007
Peer-reviewed
Oui
Volume
54
Numéro
78
Pages
1791-1797
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
BACKGROUND/AIMS: Surgical resection is a standard treatment of hepatocellular carcinoma, but liver cirrhosis is known to be associated to a high tumor recurrence rate.
METHODOLOGY: A retrospective study of 55 consecutive patients (37 males, 18 females) suffering from hepatocellular carcinoma having undergone surgical resection. Hepatocellular carcinoma developed in 29 patients with normal liver (group A) and in 26 patients with chronic liver disease (CLD) (group B). Patients were significantly older and at high-risk in Group B.
RESULTS: Radical liver resection was achieved in 98% (100% in group A; 96% in group B). Overall 2-month mortality was 2% (0% in group A; 4% in group B). The 5-year overall and disease-free survival was respectively 55% and 35%. However, the 5-year overall and disease-free survival was significantly better in Group A (71% and 59%) compared to Group B (37% and 6%) (p < 0.001), respectively. Multivariate statistical analysis demonstrated that age > 50 years, poor tumor differentiation and presence of satellite nodules were significant independent adverse predictive factors of overall and disease-free survival.
CONCLUSIONS: Resection of HCC is safe and effective with satisfactory overall and disease-free survival rates, except when underlying chronic liver disease and poor tumor differentiation are present.
Mots-clé
Adolescent, Adult, Aged, Carcinoma, Hepatocellular/surgery, Disease-Free Survival, Female, Hepatectomy, Humans, Liver/surgery, Liver Cirrhosis/pathology, Liver Cirrhosis/surgery, Liver Neoplasms/surgery, Male, Middle Aged, Multivariate Analysis, Neoplasms/pathology, Recurrence, Retrospective Studies, Risk Factors
Pubmed
Web of science
Création de la notice
20/10/2016 17:08
Dernière modification de la notice
03/03/2018 13:39
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