A new case of myelodysplastic syndrome with 6p rearrangement.

Détails

ID Serval
serval:BIB_0CD3AE4CFBA3
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
A new case of myelodysplastic syndrome with 6p rearrangement.
Périodique
Cancer genetics and cytogenetics
Auteur(s)
Jotterand-Bellomo M., Parlier V., Petite J., Beris J.
ISSN
0165-4608
Statut éditorial
Publié
Date de publication
1990
Volume
44
Numéro
2
Pages
271-4
Langue
anglais
Notes
Publication types: Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
Résumé
Bone marrow cells from a patient with refractory anemia with ringed sideroblasts were studied cytogenetically. All metaphases analyzed revealed an abnormal karyotype with complex defects. The most prominent defect consisted of a rearrangement of the short arm of chromosome 6. Until now, 6p rearrangements have been preferentially observed in myelodysplastic patients with a history of previous exposure to toxic products such as alkylating agents or environmental factors of occupational origin. Although our patient was not exposed to alkylating agents, for about 20 years he has regularly consumed important quantities of analgesics, tranquilizers, and nonsteroidal antiinflammatory drugs. The eventual relationship between sideroblastic anemia and drug abuse, as well as the existence of chromosome sites preferentially rearranged in the bone marrow cells of myelodysplastic patients, are discussed.
Mots-clé
Adult, Anemia, Refractory, Bone Marrow, Chromosome Aberrations, Chromosome Banding, Chromosomes, Human, Pair 6, Humans, Karyotyping, Male
Pubmed
Création de la notice
22/05/2009 9:58
Dernière modification de la notice
03/03/2018 13:38
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