Calcium-enriched foods and bone mass growth in prepubertal girls: a randomized, double-blind, placebo-controlled trial

Détails

ID Serval
serval:BIB_0CB7C20A7DAF
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Calcium-enriched foods and bone mass growth in prepubertal girls: a randomized, double-blind, placebo-controlled trial
Périodique
Journal of Clinical Investigation
Auteur(s)
Bonjour  J. P., Carrie  A. L., Ferrari  S., Clavien  H., Slosman  D., Theintz  G., Rizzoli  R.
ISSN
0021-9738 (Print)
Statut éditorial
Publié
Date de publication
03/1997
Volume
99
Numéro
6
Pages
1287-94
Notes
Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't --- Old month value: Mar 15
Résumé
High calcium intake during childhood has been suggested to increase bone mass accrual, potentially resulting in a greater peak bone mass. Whether the effects of calcium supplementation on bone mass accrual vary from one skeletal region to another, and to what extent the level of spontaneous calcium intake may affect the magnitude of the response has, however, not yet been clearly established. In a double-blind, placebo-controlled study, 149 healthy prepubertal girls aged 7.9+/-0.1 yr (mean+/-SEM) were either allocated two food products containing 850 mg of calcium (Ca-suppl.) or not (placebo) on a daily basis for 1 yr. Areal bone mineral density (BMD), bone mineral content (BMC), and bone size were determined at six sites by dual-energy x-ray absorptiometry. The difference in BMD gain between calcium-supplemented (Ca-suppl.) and placebo was greater at radial (metaphysis and diaphysis) and femoral (neck, trochanter, and diaphyses) sites (7-12 mg/cm2 per yr) than in the lumbar spine (2 mg/cm2 per yr). The difference in BMD gains between Ca-suppl. and placebo was greatest in girls with a spontaneous calcium intake below the median of 880 mg/d. The increase in mean BMD of the 6 sites in the low-calcium consumers was accompanied by increased gains in mean BMC, bone size, and statural height. These results suggest a possible positive effect of calcium supplementation on skeletal growth at that age. In conclusion, calcium-enriched foods significantly increased bone mass accrual in prepubertal girls, with a preferential effect in the appendicular skeleton, and greater benefit at lower spontaneous calcium intake.
Mots-clé
Body Height Body Mass Index Bone Density/*drug effects Bone Development/*drug effects Calcium, Dietary/administration & dosage/*pharmacology Child Densitometry, X-Ray Double-Blind Method Eating Female Follow-Up Studies *Food, Fortified Humans Patient Compliance
Pubmed
Web of science
Création de la notice
25/01/2008 11:31
Dernière modification de la notice
03/03/2018 13:38
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