Inhibition of aldosterone-induced antinatriuresis and kaliuresis by actinomycin D

Détails

ID Serval
serval:BIB_0CA81D03D3A2
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Inhibition of aldosterone-induced antinatriuresis and kaliuresis by actinomycin D
Périodique
American Journal of Physiology
Auteur(s)
Horisberger  J. D., Diezi  J.
ISSN
0002-9513 (Print)
Statut éditorial
Publié
Date de publication
02/1984
Volume
246
Numéro
2 Pt 2
Pages
F201-4
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Feb
Résumé
The effects of actinomycin D on short-term response to aldosterone on sodium and potassium urinary excretion were investigated in adrenalectomized glucocorticoid-substituted anesthetized rats. Aldosterone alone (1 microgram/kg followed by sustained intravenous infusion of 1 microgram X kg-1 X h-1) entailed a simultaneous antinatriuretic and kaliuretic effect after a latent period of 30-60 min. Actinomycin D (300 micrograms/kg) administered intravenously 30 min before aldosterone inhibited both the aldosterone-induced kaliuresis and antinatriuresis and the concomitant changes in plasma potassium concentration. The administration of actinomycin D alone enhanced sodium excretion in the first hour and then induced kaliuresis. These results favor the hypothesis that mineralocorticoid effects of aldosterone on sodium and potassium excretion are closely linked and may be dependent on the same mechanisms.
Mots-clé
Adrenalectomy Aldosterone/*pharmacology Aldosterone Antagonists/pharmacology Animals Dactinomycin/*pharmacology Male Natriuresis/*drug effects Potassium/*urine Rats Rats, Inbred Strains
Pubmed
Web of science
Création de la notice
24/01/2008 13:38
Dernière modification de la notice
03/03/2018 13:38
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