Ein neuer Stern am Himmel der epidermalen Proteine: Loricrin--was ist das? [A new star in the heavens of epidermal proteins: loricrin--what is it?]

Details

Serval ID
serval:BIB_0C53C862A5BF
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Ein neuer Stern am Himmel der epidermalen Proteine: Loricrin--was ist das? [A new star in the heavens of epidermal proteins: loricrin--what is it?]
Journal
Hautarzt
Author(s)
Hohl  D.
ISSN
0017-8470 (Print)
Publication state
Published
Issued date
06/1990
Volume
41
Number
6
Pages
299-301
Notes
English Abstract
Journal Article
Review --- Old month value: Jun
Abstract
A cDNA clone, encoding for a major component of the cornified cell envelope now termed loricrin, was isolated by cross-hybridization with the end domains of keratin 1 and 10. Loricrin is expressed very late in terminal epidermal differentiation in the upper stratum granulosum and is identical to the sulfur-rich component of the single type keratohyaline granule. Moreover, loricrin appears later to become cross-linked by the formation of glutamyl-lysyl-isopeptide bonds and thereby incorporated as a major component into the cornified cell envelope. In vivo, loricrin is expressed in all mammalian stratified epithelia tested so far. However, the highest levels of expression are found in humid tissues such as newborn epidermis, the epithelia of oral and anal mucosa, esophagus, foreskin, vagina and the epidermal parts of sweat ducts.
Keywords
Cell Differentiation/*genetics *Cloning, Molecular Epidermis/*cytology Gene Expression Regulation/*physiology Humans Keratins/*genetics Membrane Proteins/*genetics
Pubmed
Web of science
Create date
25/01/2008 16:36
Last modification date
20/08/2019 12:33
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