Adrenergic receptor homologies in vertebrate and invertebrate species examined by DNA hybridization.

Détails

ID Serval
serval:BIB_0C225DFEBC53
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Adrenergic receptor homologies in vertebrate and invertebrate species examined by DNA hybridization.
Périodique
Life Sciences
Auteur(s)
Palacios J.M., O'Dowd B.F., Cotecchia S., Hnatowich M., Caron M.G., Lefkowitz R.J.
ISSN
0024-3205 (Print)
ISSN-L
0024-3205
Statut éditorial
Publié
Date de publication
1989
Volume
44
Numéro
26
Pages
2057-2065
Langue
anglais
Résumé
The deduced protein sequences of the mammalian adrenergic receptors (ARs) suggest that these proteins have evolved by several ancient gene duplication events. To investigate in what species these events may have occurred DNA fragments encoding the family of adrenergic receptors from human (beta 1AR and alpha 2AR) and hamster (beta 2AR and alpha 1AR) were used to detect homologous sequences in other vertebrates, invertebrates and unicellular organisms by Southern blot hybridization analysis. Sequences homologous to hamster beta 2AR were detected in lower vertebrates, invertebrates and Dictyostelium, but not in yeast or bacteria. Within vertebrates, sequences strongly homologous to human beta 1AR and human platelet alpha 2AR were confined to the higher vertebrates only. In the invertebrates, only Drosophila contained sequences homologous to hamster alpha 1AR. Our results suggest that non-mammalian species may contain receptors homologous to the mammalian adrenergic receptors and that the sequences homologous to human beta 2AR have been the most strongly conserved.
Mots-clé
Animals, Blotting, Southern, Dictyostelium/genetics, Nucleic Acid Hybridization, Receptors, Adrenergic, alpha/genetics, Receptors, Adrenergic, beta/genetics, Sequence Homology, Nucleic Acid
Pubmed
Web of science
Création de la notice
24/01/2008 11:05
Dernière modification de la notice
20/08/2019 12:33
Données d'usage