Article: article from journal or magazin.
Case report (case report): feedback on an observation with a short commentary.
Skeletal muscle regeneration mimicking rhabdomyosarcoma: a potential diagnostic pitfall
PT - Case Reports PT - Journal Article
AIMS: We report three cases of skeletal muscle regeneration, of which two mimicked a small round cell tumour, especially a rhabdomyosarcoma. METHODS AND RESULTS: One case presented as an intramuscular mass, located in the right quadriceps of a 12-year-old male; the second patient was a 25-year-old football player who complained of painful left peroneus muscles; the third patient was a 22-year-old male who underwent an amputation of the right thigh 5 days after right leg amputation due to limb crush. Histologically, muscle biopsy specimens showed a proliferation of small round cells, either infiltrating the striated muscle in a diffuse manner or growing within and around necrotic myofibres. Immunohistochemically and ultrastructurally, the cellular population was composed of two types of cells: phagocytic cells the nuclei of which occasionally showed a wreathlike arrangement around necrotic myofibres resulting in structures resembling Langhans-type multinucleated giant cells, and proliferating satellite cells showing enlarged nuclei, prominent nucleoli, mitotic figures, myogenic differentiation and fusion features in order to form regenerating myotubes. CONCLUSIONS: Muscle regeneration is a benign process that may occasionally mimic a small round cell proliferation resembling a lymphoma or an alveolar rhabdomyosarcoma with which it should not be confused
Adult/Biological Markers/analysis/Child/Diagnosis,Differential/Humans/Immunohistochemistry/Male/Muscle,Skeletal/anatomy & histology/chemistry/physiology/Neoplasms,Muscle Tissue/Pathology/Regeneration/Rhabdomyosarcoma
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