Prediction of local and metastatic recurrence in solitary fibrous tumor: construction of a risk calculator in a multicenter cohort from the French Sarcoma Group (FSG) database.

Détails

ID Serval
serval:BIB_0A21DFF5A12F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Prediction of local and metastatic recurrence in solitary fibrous tumor: construction of a risk calculator in a multicenter cohort from the French Sarcoma Group (FSG) database.
Périodique
Annals of oncology
Auteur(s)
Salas S., Resseguier N., Blay J.Y., Le Cesne A., Italiano A., Chevreau C., Rosset P., Isambert N., Soulie P., Cupissol D., Delcambre C., Bay J.O., Dubray-Longeras P., Krengli M., De Bari B., Villa S., Kaanders JHAM, Torrente S., Pasquier D., Thariat J.O., Myroslav L., Sole C.V., Dincbas H.F., Habboush J.Y., Zilli T., Dragan T., Khan R K., Ugurluer G., Cena T., Duffaud F., Penel N., Bertucci F., Ranchere-Vince D., Terrier P., Bonvalot S., Macagno N., Lemoine C., Lae M., Coindre J.M., Bouvier C.
ISSN
1569-8041 (Electronic)
ISSN-L
0923-7534
Statut éditorial
Publié
Date de publication
01/08/2017
Peer-reviewed
Oui
Volume
28
Numéro
8
Pages
1979-1987
Langue
anglais
Notes
Publication types: Journal Article ; Multicenter Study ; Validation Studies
Publication Status: ppublish
Résumé
Solitary fibrous tumors (SFT) are rare unusual ubiquitous soft tissue tumors that are presumed to be of fibroblastic differentiation. At present, the challenge is to establish accurate prognostic factors.
A total of 214 consecutive patients with SFT diagnosed in 24 participating cancer centers were entered into the European database (www.conticabase.org) to perform univariate and multivariate analysis for overall survival (OS), local recurrence incidence (LRI) and metastatic recurrence incidence (MRI) by taking competing risks into account. A prognostic model was constructed for LRI and MRI. Internal and external validations of the prognostic models were carried out. An individual risk calculator was carried out to quantify the risk of both local and metastatic recurrence.
We restricted our analysis to 162 patients with local disease. Twenty patients (12.3%) were deceased at the time of analysis and the median OS was not reached. The LRI rates at 10 and 20 years were 19.2% and 38.6%, respectively. The MRI rates at 10 and 20 years were 31.4% and 49.8%, respectively. Multivariate analysis retained age and mitotic count tended to significance for predicting OS. The factors influencing LRI were viscera localization, radiotherapy and age. Mitotic count, tumor localization other than limb and age had independent values for MRI. Three prognostic groups for OS were defined based on the number of unfavorable prognostic factors and calculations were carried out to predict the risk of local and metastatic recurrence for individual patients.
LRI and MRI rates increased between 10 and 20 years so relapses were delayed, suggesting that long-term monitoring is useful. This study also shows that different prognostic SFT sub-groups could benefit from different therapeutic strategies and that use of a survival calculator could become standard practice in SFTs to individualize treatment based on the clinical situation.
Mots-clé
Adult, Aged, Cohort Studies, Female, France, Humans, Incidence, Male, Middle Aged, Neoplasm Metastasis, Neoplasm Recurrence, Local/epidemiology, Prognosis, Solitary Fibrous Tumors/epidemiology, Solitary Fibrous Tumors/pathology, Survival Analysis, competing risks, prognostic factors, risk calculator, solitary fibrous tumor
Pubmed
Web of science
Open Access
Oui
Création de la notice
18/09/2017 14:54
Dernière modification de la notice
20/08/2019 12:32
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