La radiotherapie conformationnelle du cancer bronchique non a petites cellules. [Conformal radiotherapy of non-small-cell lung cancer]

Details

Serval ID
serval:BIB_08C5528F6CA6
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
La radiotherapie conformationnelle du cancer bronchique non a petites cellules. [Conformal radiotherapy of non-small-cell lung cancer]
Journal
Cancer RadioThérapie
Author(s)
Mornex  F., Giraud  P., Van Houtte  P., Mirimanoff  R., Chapet  O., Loubeyre  P.
ISSN
1278-3218 (Print)
Publication state
Published
Issued date
10/1999
Volume
3
Number
5
Pages
425-36
Notes
Comparative Study
English Abstract
Journal Article
Review --- Old month value: Sep-Oct
Abstract
About one third of lung cancers initially present with a localised disease, without any curative surgery potential, because of local spread or comorbidity. Definitive radiation, alone or combined with chemotherapy, then represents the treatment of choice for these patients. The results, however, are disappointing, with a biopsy-proven local control of 10% at two years and a 5-10% five-year survival rate. These poor results may be partially explained by the difficulties in delineating the tumour volume as well as the dose limitations due to poor tolerance of surrounding normal organs. Lung parenchyma sequelae remain daily worrying events for the oncologist. The advent of 3D conformal radiation therapy (3DRT) allows progress and innovations, including the use of modern imaging techniques, sophisticated dosimetry and treatment planning, efficient immobilisation devices and on-line verification procedures. With more precise (and time-consuming) procedures, 3DRT will allow a better tumour volume delineation, an increased tumour dose and a dose limitation in normal tissues. These improvements may help increase local control and survival results. 3DRT, which has been used for several years for prostate cancer and benefits from recent imaging improvements, will now allow treatment of other locations, such as lung cancer, with conformal therapy. The few preliminary results are encouraging. This work reviews the current data and remaining questions regarding lung cancer treated with 3DRT, and presents and discusses the literature before discussing future trends in this area.
Keywords
Antineoplastic Agents/therapeutic use Carcinoma, Non-Small-Cell Lung/drug therapy/mortality/*radiotherapy Combined Modality Therapy Humans Image Processing, Computer-Assisted Lung Neoplasms/drug therapy/mortality/*radiotherapy Meta-Analysis Quality Assurance, Health Care Radiotherapy Dosage Radiotherapy Planning, Computer-Assisted *Radiotherapy, Conformal/standards Randomized Controlled Trials Reproducibility of Results Time Factors
Pubmed
Create date
24/01/2008 17:12
Last modification date
20/08/2019 12:31
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