Fractalkine regulation of microglial physiology and consequences on the brain and behavior.

Détails

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Etat: Serval
Version: Final published version
Licence: CC BY-NC-ND 4.0
ID Serval
serval:BIB_08C0774F2722
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Fractalkine regulation of microglial physiology and consequences on the brain and behavior.
Périodique
Frontiers in cellular neuroscience
Auteur(s)
Paolicelli R.C., Bisht K., Tremblay M.È.
ISSN
1662-5102 (Print)
ISSN-L
1662-5102
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
8
Pages
129
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Résumé
Neural circuits are constantly monitored and supported by the surrounding microglial cells, using finely tuned mechanisms which include both direct contact and release of soluble factors. These bidirectional interactions are not only triggered by pathological conditions as a S.O.S. response to noxious stimuli, but they rather represent an established repertoire of dynamic communication for ensuring continuous immune surveillance and homeostasis in the healthy brain. In addition, recent studies are revealing key tasks for microglial interactions with neurons during normal physiological conditions, especially in regulating the maturation of neural circuits and shaping their connectivity in an activity- and experience-dependent manner. Chemokines, a family of soluble and membrane-bound cytokines, play an essential role in mediating neuron-microglia crosstalk in the developing and mature brain. As part of this special issue on Cytokines as players of neuronal plasticity and sensitivity to environment in healthy and pathological brain, our review focuses on the fractalkine signaling pathway, involving the ligand CX3CL1 which is mainly expressed by neurons, and its receptor CX3CR1 that is exclusively found on microglia within the healthy brain. An extensive literature largely based on transgenic mouse models has revealed that fractalkine signaling plays a critical role in regulating a broad spectrum of microglial properties during normal physiological conditions, especially their migration and dynamic surveillance of the brain parenchyma, in addition to influencing the survival of developing neurons, the maturation, activity and plasticity of developing and mature synapses, the brain functional connectivity, adult hippocampal neurogenesis, as well as learning and memory, and the behavioral outcome.
Mots-clé
CX3CR1, behavior, development, fractalkine, microglia, neurogenesis, neurons, synapses
Pubmed
Web of science
Open Access
Oui
Création de la notice
18/12/2018 11:42
Dernière modification de la notice
18/06/2019 6:26
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