Polysomy 8 defines a clinico-cytogenetic entity representing a subset of myeloid hematologic malignancies associated with a poor prognosis: report on a cohort of 12 patients and review of 105 published cases.

Détails

ID Serval
serval:BIB_07F6F80B0886
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Polysomy 8 defines a clinico-cytogenetic entity representing a subset of myeloid hematologic malignancies associated with a poor prognosis: report on a cohort of 12 patients and review of 105 published cases.
Périodique
Cancer genetics and cytogenetics
Auteur(s)
Beyer V., Mühlematter D., Parlier V., Cabrol C., Bougeon-Mamin S., Solenthaler M., Tobler A., Pugin P., Gregor M., Hitz F., Hess U., Chapuis B., Laurencet F., Schanz U., Schmidt P.M., van Melle G., Jotterand M.
ISSN
0165-4608
Statut éditorial
Publié
Date de publication
2005
Peer-reviewed
Oui
Volume
160
Numéro
2
Pages
97-119
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review - Publication Status: ppublish
Résumé
Tetrasomy, pentasomy, and hexasomy 8 (polysomy 8) are relatively rare compared to trisomy 8. Here we report on a series of 12 patients with acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), or myeloproliferative disorder (MPD) associated with polysomy 8 as detected by conventional cytogenetics and fluorescence in situ hybridization (FISH). In an attempt to better characterize the clinical and hematological profile of this cytogenetic entity, our data were combined with those of 105 published patients. Tetrasomy 8 was the most common presentation of polysomy 8. In 60.7% of patients, polysomy 8 occurred as part of complex changes (16.2% with 11q23 rearrangements). No cryptic MLL rearrangements were found in cases in which polysomy 8 was the only karyotypic change. Our study demonstrates the existence of a polysomy 8 syndrome, which represents a subtype of AML, MDS, and MPD characterized by a high incidence of secondary diseases, myelomonocytic or monocytic involvement in AML and poor overall survival (6 months). Age significantly reduced median survival, but associated cytogenetic abnormalities did not modify it. Cytogenetic results further demonstrate an in vitro preferential growth of the cells with a high level of aneuploidy suggesting a selective advantage for polysomy 8 cells.
Mots-clé
Acute Disease, Adult, Aged, Aged, 80 and over, Aneuploidy, Chromosomes, Human, Pair 8, Female, Humans, In Situ Hybridization, Fluorescence, Karyotyping, Leukemia, Myeloid, Male, Middle Aged, Myelodysplastic Syndromes, Myeloproliferative Disorders, Prognosis, Survival Rate
Pubmed
Web of science
Création de la notice
25/01/2008 15:18
Dernière modification de la notice
03/03/2018 13:29
Données d'usage