Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
MET: a promising anticancer therapeutic target.
Nature Reviews. Clinical Oncology
Publication types: Journal Article ; ReviewPublication Status: epublish
The MET pathway is dysregulated in many human cancers and promotes tumour growth, invasion and dissemination. Abnormalities in MET signalling have been reported to correlate with poor clinical outcomes and drug resistance in patients with cancer. Thus, MET has emerged as an attractive target for cancer therapy. Several MET inhibitors have been introduced into the clinic, and are currently in all phases of clinical trials. In general, initial results from these studies indicate only a modest benefit in unselected populations. In this Review, we discuss current challenges in developing MET inhibitors--including identification of predictive biomarkers--as well as the most-efficient ways to combine these drugs with other targeted agents or with classic chemotherapy or radiotherapy.
Animals, Antineoplastic Agents/therapeutic use, Humans, Neoplasms/drug therapy, Neoplasms/genetics, Proto-Oncogene Proteins c-met/antagonists & inhibitors, Proto-Oncogene Proteins c-met/genetics, Signal Transduction/drug effects
Web of science
Last modification date