Protection of axotomized ganglion cells by salicylic acid

Details

Serval ID
serval:BIB_03FDEDE728E2
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Protection of axotomized ganglion cells by salicylic acid
Journal
Brain Research
Author(s)
Castagné V., Barnéoud P., Clarke P.G.H.
ISSN
0006-8993
Publication state
Published
Issued date
1999
Peer-reviewed
Oui
Volume
840
Number
1-2
Pages
162-166
Language
english
Abstract
Neuronal survival is influenced by the redox environment, and it has been shown that antioxidants protect developing neurons from the effects of axotomy. Here, we show that the intraocular injection of salicylic acid (SA) reduces the number of dying axotomized ganglion cells in the chick embryo. The antioxidant properties of SA are probably responsible for its protective effects, whose U-shaped dose-dependency matches that of several other antioxidants. We conclude that SA protects axotomized neurons by maintaining the redox status near an optimal set-point.
Keywords
Neuronal death, Antioxidant, Salicylic acid, Redox status, Chick embryo, Retina
Web of science
Create date
20/01/2008 17:49
Last modification date
20/08/2019 12:25
Usage data