Article: article from journal or magazin.
Enhancement of Fc gamma receptor expression in interferon-treated mice.
European Journal of Immunology
Treatment of C3H mice with partially purified or highly purified virus-induced interferon resulted in a marked increase in the expression of Fcgamma receptors (Fcgamma R) on splenic lymphocytes, mesenteric lymph node cells and thymocytes from cortisone-treated mice. An increase on Fcgamma R on splenic lymphocytes was seen as early as 5 h and lasted at least 72 h after a single injection of interferon. We suggest that enhancement of Fcgamma R is one of the mechanisms by which interferon exerts some immunostimulating effects in vivo.
Animals, Antibody Specificity, Binding Sites, Antibody, Female, Immunoglobulin G/metabolism, Interferons/pharmacology, Iodine Radioisotopes, Lymph Nodes/metabolism, Male, Mice, Mice, Inbred C3H/immunology, Mice, Nude/immunology, Receptors, Fc/immunology, Spleen/immunology, Spleen/metabolism, Thymus Gland/metabolism
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