Hyperpolarization without persistent radicals for in vivo real-time metabolic imaging

Détails

ID Serval
serval:BIB_039962233088
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Hyperpolarization without persistent radicals for in vivo real-time metabolic imaging
Périodique
Proceedings of the National Academy of Sciences of the United States of America
Auteur(s)
Eichhorn T.R., Takado Y., Salameh N., Capozzi A., Cheng T., Hyacinthe J.N., Mishkovsky M., Roussel C., Comment A.
ISSN
0027-8424 (Print)
1091-6490 (Electronic)
ISSN-L
0027-8424
Statut éditorial
Publié
Date de publication
2013
Peer-reviewed
Oui
Volume
110
Numéro
45
Pages
18064-18069
Langue
anglais
Notes
Publication types: Physical Sciences ; Biological Sciences ; research-article Identifiant PubMed Central: PMC3831441
Résumé
Hyperpolarized substrates prepared via dissolution dynamic nuclear polarization have been proposed as magnetic resonance imaging (MRI) agents for cancer or cardiac failure diagnosis and therapy monitoring through the detection of metabolic impairments in vivo. The use of potentially toxic persistent radicals to hyperpolarize substrates was hitherto required. We demonstrate that by shining UV light for an hour on a frozen pure endogenous substance, namely the glucose metabolic product pyruvic acid, it is possible to generate a concentration of photo-induced radicals that is large enough to highly enhance the (13)C polarization of the substance via dynamic nuclear polarization. These radicals recombine upon dissolution and a solution composed of purely endogenous products is obtained for performing in vivo metabolic hyperpolarized (13)C MRI with high spatial resolution. Our method opens the way to safe and straightforward preclinical and clinical applications of hyperpolarized MRI because the filtering procedure mandatory for clinical applications and the associated pharmacological tests necessary to prevent contamination are eliminated, concurrently allowing a decrease in the delay between preparation and injection of the imaging agents for improved in vivo sensitivity.
Mots-clé
Carbon Isotopes/chemistry, Free Radicals/chemistry, Magnetic Resonance Imaging/methods, Metabolism/physiology, Molecular Imaging/methods
Pubmed
Web of science
Création de la notice
11/07/2016 11:04
Dernière modification de la notice
03/03/2018 13:20
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