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Endoplasmic reticulum calcium transport ATPase expression during differentiation of colon cancer and leukaemia cells.
Biochemical and Biophysical Research Communications
Date de publication
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review Publication Status: ppublish
The calcium homeostasis of the endoplasmic reticulum (ER) is connected to a multitude of cell functions involved in intracellular signal transduction, control of proliferation, programmed cell death, or the synthesis of mature proteins. Calcium is accumulated in the ER by various biochemically distinct sarco/endoplasmic reticulum calcium transport ATPase isoenzymes (SERCA isoforms). Experimental data indicate that the SERCA composition of some carcinoma and leukaemia cell types undergoes significant changes during differentiation, and that this is accompanied by modifications of SERCA-dependent calcium accumulation in the ER. Because ER calcium homeostasis can also influence cell differentiation, we propose that the modulation of the expression of various SERCA isoforms, and in particular, the induction of the expression of SERCA3-type proteins, is an integral part of the differentiation program of some cancer and leukaemia cell types. The SERCA content of the ER may constitute a new parameter by which the calcium homeostatic characteristics of the organelle are adjusted. The cross-talk between ER calcium homeostasis and cell differentiation may have some implications for the better understanding of the signalling defects involved in the acquisition and maintenance of the malignant phenotype.
Animals, Calcium-Transporting ATPases/antagonists & inhibitors, Calcium-Transporting ATPases/genetics, Cell Differentiation, Colonic Neoplasms/enzymology, Colonic Neoplasms/pathology, Endoplasmic Reticulum/enzymology, Gene Expression Regulation, Humans, Leukemia, Myeloid/enzymology, Leukemia, Myeloid/pathology, Sarcoplasmic Reticulum Calcium-Transporting ATPases, T-Lymphocytes/enzymology, Transcription, Genetic
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