Amiloride-sensitive Na channels

Details

Serval ID
serval:BIB_02427B980E41
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Amiloride-sensitive Na channels
Journal
Current Opinion in Cell Biology
Author(s)
Horisberger  J. D.
ISSN
0955-0674 (Print)
Publication state
Published
Issued date
08/1998
Volume
10
Number
4
Pages
443-9
Notes
Journal Article
Review --- Old month value: Aug
Abstract
The emerging epithelial Na channel/degenerin family of sodium channels is rapidly expanding, in particular with new members expressed in mammalian neurons and potentially involved in pain transmission. Experimental evidence supports a four-subunit stoichiometry for these channels (although this is still controversial), and basic functional elements (pore and selectivity filter, amiloride binding site, gating) have started to be attributed to specific domains of the protein. Although much remains to be done, in the past year progress has been made in the understanding of several regulatory mechanisms: the control of epithelial Na channel translation by mineralocorticoid hormones, the role of endocytosis and ubiquitination for degradation in the control of the channel density and the role of extracellular proteases.
Keywords
*Amiloride Animals Epithelial Sodium Channel Humans Ion Channels/drug effects/*genetics Nerve Tissue Proteins/drug effects/*genetics Sodium Channels/drug effects/*genetics
Pubmed
Web of science
Create date
24/01/2008 12:38
Last modification date
20/08/2019 12:24
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